Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network
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چکیده
منابع مشابه
Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway.
(-)-Epigallocatechin-3-gallate (EGCG) is a well-known chemoprevention factor. Recent studies have revealed that EGCG triggers cancer cells undergoing apoptosis through p53-dependent pathway. How EGCG activates p53-dependent apoptosis is not fully understood. In the present study using JB6 cell as a model system, we have shown that EGCG can negatively regulate protein serine/threonine phosphatas...
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Antioxidant Network Expression Abrogates 1 Oxidative Post-Translational Modifications in Mice 2 3 Mital R, Zhang W, Cai M, Huttinger ZM, Goodman LA, Wheeler DG, 4 Ziolo MT, Dwyer KM, d'Apice AJF, Zweier JL, He G, Cowan PJ, and Gumina RJ 5 6 Division of Cardiovascular Medicine, 7 Department of Physiology and Cell Biology and 8 Davis Heart and Lung Research Institute, The Ohio State University, C...
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Various post-translational modifications (PTMs) fine-tune the functions of almost all eukaryotic proteins, and co-regulation of different types of PTMs has been shown within and between a number of proteins. Aiming at a more global view of the interplay between PTM types, we collected modifications for 13 frequent PTM types in 8 eukaryotes, compared their speed of evolution and developed a meth...
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Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...
متن کامل(−)-Epigallocatechin-3-gallate modulates peripheral immunity in the MPTP-induced mouse model of Parkinson's disease
(-)-Epigallocatechin-3-gallate (EGCG) is the most widely studied catechin in green tea and has been identified to regulate immune function. The objective of the present study was to explore the possible application of EGCG in the treatment of Parkinson's disease (PD) by examining its effects on the peripheral immune system in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)‑induced PD mo...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2021
ISSN: 1949-2553
DOI: 10.18632/oncotarget.27963